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We note a progressive, specific silencing of alternate lineage genes in certain cell types coinciding with H3K27me3 enrichment, though expression silencing is maintained in its absence.
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Neurodegenerative disorders are a subset of disabling pathologies characterized, in part, by a progressive and specific loss of certain brain cell populations.
While such a continuum is controlled by progressive subsidence, specific collapse geometries result from secondary contributory factors (roof aspect ratio, collapse symmetry, pre-existing faults).
"That's why Governor O'Malley has set bold, progressive, and specific goals to make our economy work for more Americans".
These data indicate that PRV induces a progressive pain specific to the pelvic region, consistent with previous observations [13].
As yet it is unknown whether iPS cells can differentiate into functional replacement cells for use in the treatment of progressive diseases specific to the visual system.
As in any type of training, for improvement to occur it is crucial to maintain a progressive and specific training load for each of the participants.
They failed, however, to reproduce the combination of progressive and specific dopamine cell loss, protein aggregation and manifestation of parkinsonian-like symptoms [ 8].
Type 1 diabetes mellitus results from the progressive and specific autoimmune destruction of insulin-secreting pancreatic B-cells, which develops over a period of years and continues after the initial clinical presentation.
AD is caused by a progressive and specific degeneration of neurons; with extracellular deposition of β-amyloid plaques, intracellular deposition of neurofibrillary tangles, which lead to neurotoxicity and synaptic loss being hallmarks of the disease.
Furthermore, the progressive tissue-specific changes in ETC function may be a mechanism for the differential rate of tissue-specific aging in higher organisms.
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