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Progressive shrinkage of distal dendrites of Purkinje cells and decreased currents through α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid and γ-aminobutyrate type A receptors in CA1 neurons were also observed.
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ILK mutant NCCs on all substrates tested exhibited progressive cell shrinkage and detachment during the course of culture.
However, progressive cortical shrinkage over time has been estimated at approximately 37 cm in patients in comparison with healthy subjects in a review of six studies [ 6] and thus might fully explain ventricular enlargement.
Although progressive tumor shrinkage in vivo was observed 3-4 dafterfter PIT, even after only a single administration of mAb-IR700 and a single exposure of NIR light, nonetheless there is uncertainty over how quickly cell death occurs [ 4].
It is now well established from a plethora of comparative genome studies that the universal trend among endosymbiotic bacteria is the steady accumulation of deleterious mutations, high rates of nucleotide substitutions (reflected by a high AT-content), and progressive genome shrinkage [ 7, 8, 21].
SCH induces progressive and severe shrinkage of RSN bodies.
For example, valinomycin caused gradual and progressive cell volume shrinkage while ouabain did not show the same volume change.
SCLC's response rates to ABT-263 in early clinical studies have also been quite variable, ranging from minimal tumor shrinkage to progressive disease.
Partial response was defined as a decrease of 50% or more in the product of two diameters which is maintained for at least 1 month according to WHO criteria, a minor response was 25 49% shrinkage, and progressive disease was a 25% increase.
Fifty-five per cent achieved objective tumour response, and a further 27% minor tumour shrinkage; none had progressive disease.
An age-dependent decline in osteocyte lacunar size over the human lifespan [135] is also suggestive of generally changed function of surviving osteocytes, since progressive maturation is associated with shrinkage in volume and changes in the profile of the bioactive molecules osteocytes express [65].
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