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Although recently challenged [31], the classic priming concept posits that LID results from a progressive sensitization through repeated administrations.
In the current study we have monitored the progressive sensitization to stress upon the immortalization of normal cells and during the initial steps of transformation, characterizing the changes in the pre-malignant stage.
Because a female fetus has no Y-chromosome and produces no such proteins, the progressive sensitization occurs during the gestation of only a male fetus.
Similar(56)
Repeated intermittent cocaine administration produces a progressive increase (sensitization) in the motor stimulatory action of cocaine.
These findings indicate that a progressive increase in sensitization to EF occurs during carcinogenesis and is evident at the point of preneoplastic dysplasia.
Is progress necessarily progressive?
Neural sensitization is the progressive amplification of responsivity by the passage of time between repeated, intermittent exposures.
Behavioral sensitization, defined as a progressive increase in the locomotor stimulant effects elicited by repeated exposure to drugs of abuse, has been used as an animal model for drug craving in humans.
Behavioral sensitization corresponds to a progressive enhancement of locomotor responses following repeated exposure to drug abuse [25].
In CM, sensitization phenomena are associated with progressive and more pervasive functional and neuroanatomical changes [54].
Following repeated treatments, the same drugs induce a progressive increase in locomotor response called behavioral sensitization.
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