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As noble as intentions might be, who ever heard of progressive regeneration?
TRICOL decellularized substitutes exhibited ex vivo progressive regeneration without signs of degeneration (calcifications, fibrosis, and/or thrombosis) or immune rejection.
This evidence indicates that soluble E-cadherin may serve as a prospective tumor marker that accurately reflects the progressive regeneration of E-cadherin at tumor sites.
Thus, it is evident that soluble E-cadherin in circulation can be used as a prospective tumour marker that accurately reflects the progressive regeneration of E-cadherin at tumour sites, potentially induced by tumour-associated proteolytic degradation.
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Recently, a number of investigations have demonstrated that the involvement of a ductular reaction (DR), which is a reactive lesion at the portal tract interface comprising increased bile ductules with an accompanying complex of stromal and inflammatory cells, has been implicated in the pathogenesis of progressive fibrosis, regeneration and hepato-carcinogenesis in chronic liver disease [ 5, 6].
Histological staining and immunostaining further confirmed the progressive directional nerve regeneration and branching behavior across the entire NGC length.
Therefore, the PlnOE mouse does not closely resemble dystrophic myopathy; however, central nucleation in the face of low regeneration, progressive fibrosis, and moderate elevations in CK levels is also found in CNM (Jungbluth et al., 2008).
Impairment of vascular regeneration precedes progressive glomerulosclerosis in anti-Thy 1 glomerulonephritis.
Association of CDK inhibitor p21 with impaired liver regeneration and progressive liver fibrosis has been reported earlier [ 22].
Despite the functional exhaustion of MuSCs has been implicated in the progressive decline of the regeneration potential of dystrophic mice (Blau et al, 1983; Sacco et al, 2010), the cellular and molecular effectors of the regeneration/degeneration switch remain unknown.
The progressive nerve injury and regeneration may have resulted from the degradation of cartilage; the physical wearing of cartilage leads to exposure and degradation of subchondral bone, where sensory nerve ingrowth and pain-related mediators increase [ 43].
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