Compared to the MRI and the evolution, the CDUS presented a sensitivity of 100% and a specificity of 90% for the detection of progressive recurrence.
In this context, the current results support earlier reports of Khettry et al. [ 30] and Ciccorossi et al. [ 31] that high viral load pre-LT was correlated with more progressive recurrence of HCV and higher early (1 week) posttransplantation viral loads (≥2.5 × 10 IU/mL) are at risk for significant recurrent hepatitis C.
16 Following fasciectomy, a 3-year recurrence rate of 12% has been reported in two studies; in the first study, 4 of 33 hands had more than 30° increase in joint contracture compared with 6 weeks, 11 and in the second study, 11 of 90 fingers showed progressive recurrence of PIP joint contracture but no specific definition of recurrence was stated.
Invasive UTUCs are often characterized by progressive multifocal recurrence, even following adjunctive radiotherapy or systemic chemotherapy, and patients may ultimately die due to metastasis [ 46, 47].
Triple-negative tumours have a propensity for early and rapidly progressive metastatic recurrence and, as a group, respond less favourably to chemotherapy (Dent et al, 2007; Liedtke et al, 2008; Tan et al, 2008).
Uncontrolled progressive local recurrences, hardly palliated by irradiation or chemotherapy, have brought a miserable death to tens of millions of patients.
PFS was counted from the date of randomisation until progressive disease or recurrence or death of any cause in the Nordlinger trial [ 15].
Several lines of evidence indicate that there is a genetic component in human NTDs, the clearest indication being the progressive increase in recurrence risk following affected pregnancies (Harris and Juriloff, 2007).
Although a number of therapies, such as surgery, limb perfusion, systemic chemo- or immunochemotherapy, and radiotherapy are currently in use for this situation, management of advanced melanoma with skin and soft-tissue metastases can be a major challenge, particularly in cases of rapidly progressive disease, multiple recurrences, and extensive previous therapy.
They are typically well-circumscribed, classified as grade I by the World Health Organization (WHO), but recurrence or progressive disease occurs in about 10-20% of cases.
However, in each of these studies, most participants experienced a recurrence of progressive β-cell loss, indicating that tolerance was not achieved.
