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The algorithm evaluated long-term prescriptions, with special emphasis on significant polypharmacy (five or more prescriptions), progressive discontinuation of benzodiazepines, and nutritional or vitamin supplementation.
Special emphasis was placed on the importance of the number of drugs, the progressive discontinuation of benzodiazepines and the use of vitamin supplementation.
Clinical experience currently consists only of a few isolated cases or short series in which the administration of HIET substantially improved cardiovascular conditions in life-threatening CCB poisonings, allowing the progressive discontinuation of vasoactive agents.
Adult critically ill patients mechanically ventilated for more than 24 hours in the adult intensive care unit of the Albert Einstein Hospital, São Paulo, Brazil, were randomly assigned to be weaned either by progressive discontinuation of pressure support ventilation (PSV) with SmartCare™.
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Future studies should compare the effect of different sedative agents, and the impact of progressive opioid discontinuation compared with abrupt discontinuation on ICU-acquired infection rates.
Further, the impact of progressive opioid discontinuation on the risk of ICU-acquired infection should be compared with abrupt discontinuation.
Discontinuation of anti-viral therapy is the only way to prevent progressive thrombocytopenia; however, discontinuation of therapy may reduce the rate of viral clearance and sustained virological response (SVR) [ 8].
The progressive flattening and discontinuation of the ependymal lining with increasing ventriculomegaly was distinct.
There were 31% patients with stable and 36% with progressive disease or discontinuation of the therapy before re-staging.
Two patients died after radiographic evidence of progressive disease and discontinuation of study drugs, and one patient died of pneumonia considered unrelated to either study drug.
Main reasons for treatment discontinuation were progressive disease and toxicity.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com