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There are at least two reasons for this progressive deficiency.
Transient MCAO induce a progressive deficiency in spatial performance related to impaired hippocampal function [ 22].
As mentioned previously, subjects with type 2 diabetes exhibit progressive deficiency of insulin as a consequence of pancreatic β-cell apoptosis.
One young adult (subject 9) had biochemical evidence over 5 years of a progressive deficiency of brain dopamine but without clinical features of Parkinsonism.
Bone disorders, mineral abnormalities and vascular calcification in individuals with moderate to advanced CKD seem to be related to a progressive deficiency of active vitamin D and worsening secondary hyperparathyroidism.
It is likely that progressive deficiency of insulin, a powerful anabolic hormone, may be responsible for this decline, suggesting that early insulin therapy may be beneficial in patients with cystic fibrosis before the onset of CFRD as currently defined.
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These changes are directly related to reduced basal metabolic rate and progressive deficiencies in most other physiological functions that are responsible in a large part for increased weakness, falls, and fractures, leading to nursing home admission and loss of independence.
When tested with a panel of K56-2 mutants with progressive deficiencies in lipopolysaccharide (LPS) structure (from the O-antigen to the core) [ 31, 32], both phages were able to infect each mutant, suggesting that neither KL1 nor AH2 uses LPS as a major receptor.
Some people progress along the road from initial infection to progressive immune deficiency to life-threatening illness at the expected pace, then with treatment head right back again to health.
Because progressive insulin deficiency primarily is responsible for hyperglycemia as NGT individuals progress to IGT to type 2 diabetes (9– 15, 16, 16, 26, 28– 31), GLP-1 analogs represent a logical therapeutic intervention for treatment of IGT.
Since juveniles frequently had food in the gut and released fecal pellets, they could have suffered a progressive nutritional deficiency because of the limited conditions of laboratory cultures.
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CEO of Professional Science Editing for Scientists @ prosciediting.com