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One possibility is that, over time, aberrant DNA repair results in a progressive accumulation of oxidative damage to DNA.
Metallic tubes experiences a progressive accumulation of ovalisation, or ratchet, under cyclic inelastic bending.
Asymmetric cyclic loading in the plastic region can leads to progressive accumulation of permanent strain.
Alexander Hamilton described the progressive accumulation of debt as "perhaps the natural disease of all governments".
Progressive accumulation of α-synuclein (α-syn) and exposure to environmental toxins are risk factors that may both concur to Parkinson's disease (PD) pathogenesis.
Exposure of the rat erythrocytes to NaF was accompanied by progressive accumulation of peroxides, while superoxide (O2−) production was insignificant.
Further examination of kidney and muscle pathologies revealed a progressive accumulation of CD45+ cells, first affecting the kidneys.
Progressive accumulation of antigen loss variants resulted in a viral preparation with lower immunogenicity after serial passage.
The enzyme defect leads to progressive accumulation of glycosphingolipids (GL) in all kinds of cells, tissues, organs, and body fluids.
The progressive accumulation of connective tissue results in destruction of normal tissue architecture and internal organ failure.
PS19 Transgenic (Tg) mice express the P301S mutant form of human tau and develop progressive accumulation of neurofibrillary tangles with age.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com