How defects in one or more 5q genes trigger MDS or contribute to malignant progression in conjunction with additional chromosomal abnormalities remains unknown [10].
In breast cancer tissue from patients, the downregulation of Bim expression has been associated with breast cancer progression, in conjunction with downregulation of SIAH1 expression [ 66].
Cyclin D proteins represented interesting candidates because they are central for coordinating G1 progression in conjunction with their catalytic partners CDK4/6.
Novel, effective immunotherapeutic interventions may enable viral control and retard disease progression either in conjunction with or after termination of HAART [2], [15].
Our sensitive and specific miRNA panel, in combination with newly identified panels, may enable more precise measurement of disease progression, and in conjunction with current therapy options, may herald an increase in overall survival.
Interestingly, at semi-permissive temperature the deletion of SAS2 exacerbates the low origin activity caused by a mutation in orc2 and delays progression through S-phase in conjunction with orc2 mutations [18].
Second, the study did not include long-term follow-up data for progression to active TB in conjunction with the results of the TST and QFT-IT.
During the progression of hepatocellular carcinoma, and in conjunction with epithelial-mesenchymal transition (EMT), PDGF-A as well as PDGFRα and β are induced [ 199].
However, in conjunction with the progression of the disease, long-term L-DOPA treatment leads to the development of adverse responses including debilitating L-DOPA-induced dyskinesias (LIDs) that can include choreic, hyperkinetic movements or dystonic movements [1], [2], [3].
In both studies the methods used to determine glaucoma progression were cup-to-disc ratio in conjunction with VF testing [ 19] and with VF changes [ 20].
As a further confirmation of the CpG island microarrays, we identified seven clones whose methylation profile predicted their loss or gain in expression with disease progression by analyzing our methylation data in conjunction with Wu et al.'s expression data.
