Given the high level in incidence rate and mortality rate of colon cancer, it would be important to better understand the biological basis of tumor development and progression, to develop markers for assessing onset or prediction of therapy outcome, as well as to identify targets for the development of novel therapies.
"I've done a number of sales on the SoHo side of Broadway, and it seems to me a very natural progression to develop the area below Canal Street," said Susan Wires, a broker at the brokerage firm Stribling & Associates, which is marketing 6 Cortlandt Alley with her partner, Leila Yusuf.
Thus, abundant kif21b expression is an independent predictor for accelerated progression to develop EDSS 6.0 (Additional file 1: Table S5).
Both attempts lead to inhibition of VEGF signaling, but after prolonged treatment alternative pathways cause resistances and further angiogenic processes and tumor progression to develop [ 8].
Clinicians need to predict prognosis of Alzheimer's disease (AD), and researchers need models of progression to develop biomarkers and clinical trials designs.
First, we assumed that the progression rates to develop active TB were constant throughout the whole study period, which might underestimate the progression rates in the earlier years and overestimate it more recently, due to socio-economic improvements or other factors.
Recent studies have shown that miRNAs play a fundamental role in the invasion and metastasis of HCC [21], thereby opening a novel avenue to investigate the molecular mechanism of HCC progression and to develop potential therapeutics against HCC.
Relevant animal models are vital to understand the processes involved in tumor progression and to develop new therapies.
The analysis of clinical specimens is expected to provide expression patterns that may allow to identify which patients would respond to intravesical or systemic treatments, or present a higher progression risk to develop invasive or metastatic disease.
Most recurrences being detected by imaging or medical examination, it is essential that highly specific, sensitive and less invasive markers are identified to predict response to treatment, disease progression, and to develop personalized therapies.
