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Considering for instance diabetes, this means to rely on the prediction of risks of disease development and also on the control of the disease progression to avoid further well-known complications.
The DNA damage checkpoint works together with cyclin-dependent kinases (CDKs), master regulators of cell cycle progression, to avoid HR-mediated genetinstabilityithroughugh post-translational modifications of recombination proteins.
While many clinical trials include HRQoL assessments as trial outcomes, a major limitation in evaluating this relationship is that HRQoL assessments are often only administered until disease progression based on imaging results (which may precede symptomatic progression) to avoid the confounding effects of subsequent therapies 1 4 and to ease administrative burden.
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Main Outcome Measures: Cessation of curve progression; ability to avoid bracing or surgery; and sustained curve regression of at least 5° on radiograph after treatment completion.
The progression was staggered to avoid confusion.
However, the majority of OA patients may be more suited for conservative management of OA, to either minimize symptoms in the short term, or ultimately prevent progression of OA to avoid the need for TJA.
First, since we evaluate the progression of CACS, to avoid the extreme percent increases among individuals with little or no baseline calcification, we excluded subjects with baseline calcification scores below 30 in the relative change analyses.
Primary end point is progression-free survival, to avoid confounding by possible crossover between two arms and the sample size is 200 patients with EGFR mutations.
To identify novel immunogenetic factors specific to C. atys that may be involved in the ability of this species to avoid progression to AIDS, we established a bioinformatic pipeline for a comparative protein analysis (Fig. 1 and Extended Data Fig. 1, see Methods for details).
Treatment with high-dose prednisone and azathioprine was started to avoid progression and subsequent visual loss in the other eye.
Lastly, in patients with very early disease, HTO may be a disease modifying operation to avoid progression of osteoarthritis.
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