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To account for patients entering the model at varying rates of disease progression, the time horizon was adjusted.
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Our interpretation of progression at the time of screening potentially includes both early and late progressors because of uncertainty of the timing of progression to active disease.
Time to progression was the time elapsed from inclusion until detection of progressive disease.
For all patients, time to progression was the time from the start of treatment to the time of documented disease progression.
Time to progression (i.e. time between the start of treatment and the first objective evidence of tumour progression, or the time to censoring) was estimated by the Kaplan Meier method.
Patients 8, 16, 25, 31 and 40 were secondarily excluded because of disease progression at the time of diagnosis.
For event-driven controllers it is the occurrence of an event, instead of the autonomous progression of the time what decides when the signal sampling should be made.
However, in patients, exhausted by the disease and rounds of systemic therapy, and with cancer progression over the time needed to assemble that response, it is hardly possible.
In the constant progression scenario, the time window might be shorter than the duration of infection.
Ten patients (33%) had developed disease progression at the time of the first evaluation.
Eighteen of the 21 patients had disease progression at the time of analysis.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com