Sentence examples for progression the development of from inspiring English sources

While metabolic reprogramming is now recognized as a hallmark of tumorigenesis and tumor progression, the development of metabolic-targeted therapy remains a challenge.

Owing to the widespread role of ErbB receptor activation in tumour growth and progression, the development of ErbB inhibitors has been a subject of intense interest.

Considering that myofibroblasts are key regulators of tissue remodeling [ 10] and a major source of ECM production [ 11], which drives tumor progression, the development of anoikis-resistant myofibroblasts may be an essential event during stromal tissue remodeling before tumor invasion.

However, in some cases with chronic use, the dose of opioids may increase because of disease progression, the development of tolerance and/or the development of a state of abnormal high pain sensitivity (hypersensitivity) that opioids themselves may induce.

Later follow-up imaging studies should be aimed at detecting the recurrence of the treated lesion (i.e. local tumour progression), the development of new hepatic lesions, or the emergence of extrahepatic disease.

Moving forward, the R26PR mouse line will allow for further dissection of CIC formation and progression, the development of therapeutic strategies to target CICs and modeling of additional cancer types using available Cre drivers.

The failure to report progression of visual loss limited the ability to explore the impact of diabetic retinopathy progression before the development of PDR or SVL.

What remains to be seen is whether preeclamptic patients truly have IAH, at what pressure does this occur, and whether IAH has a significant role the in the progression of the development of severe preeclampsia or HELLP.

Activation of the Hedgehog signalling pathway contributes to cancer progression and the development of myeloid leukaemia stem cell therapeutic resistance.

To elucidate the structure and regulation of IP3R channels at the molecular level is of paramount importance to understand the disease progression and the development of targeted therapeutics.

Using these cells, researchers can study the mechanism of the disease progression for the development of new drugs.