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The interim futility analysis was based on all events (progressions or deaths without documented progression) that occurred before 30 November 2008 (i.e., more than 3 years from the start of the trial).
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We chose disease progression up to 96 h from ED presentation to identify sepsis progression that occurs early in the hospital course.
However, during tumour progression that occurs in up to 20 30% of cases, cellular dedifferentiation is present, and is usually accompanied by more aggressive growth, metastatic spread and loss of iodide uptake ability [ 4].
Indeed, laquinimod prevented the progression of demyelination that occurred over 30 days in vehicle-treated animals; this was mainly due to an inhibition of the expansion of existing lesions and not due to the prevention of the formation of new lesions.
In comparing change in costs over time incurred by patients who did and did not progress (Table 3), the annualized follow-up costs among those who progressed comingles costs that occurred prior to progression with those that occurred following progression.
Viewed globally, the gene expression changes that occurred during progression of fruit growth, maturation, and ripening were extensive and dynamic.> -wrap-foot> Eacellell in the table represents a comparison between two sample types.
We showed that IIB-BR-G-MTS6 metastatic cells exhibited significant protein expression changes as compared with the parental non-metastatic cell line and have different phenotypic characteristics associated to their metastatic behavior, probably reflecting changes that occurred during progression from primary tumor growth and metastatic dissemination.
This presented an opportunity to describe the successional progression that occurs where thicket topsoil was used for revegetation.
In the present analysis, the progression type (RECIST, CA125, or symptomatic) that occurred first was identified for each patient.
The shared mutations we identified were present in all of the tumor subpopulations and thus represent the earliest mutations that occurred during tumor progression.
Interpretation of these clinical studies is, of course, dependent on the definition of remission and the extent of subclinical synovitis and radiological progression that may occur in a patient in whom arthritis seems quiescent.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com