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Patients who have responded and then progress move directly to the Progression state from the Response state.
Composition and structure of extracellular matrix, along with tumor vasculature, is highly variable and dependent on cancer type, location, and progression state, along with patient-specific characteristics [11].
Remaining subsets (sets 1, 5, 6, and 10) were considered specifically regulated in the respective progression state.
Furthermore, a relatively high number of both activating and inhibitory reactions target p53, which was void of detectable differential expression in either progression state.
We constructed separate background sets for transgenic and tumor cells by randomly sampling 1000 genes with fold changes between 0.9 and 1.1 in the respective progression state.
Of these, HNF6 was significantly downregulated in tumor, whereas PPAR-gamma exhibited a progression state specific profile with downregulation in the transgenic state and significant upregulation in tumor.
Similar(37)
However, for an 18th-century bookseller, say John Murray, whose imprint came to publish Byron, Austen and Darwin, the service offered by Amazon could seem a natural progression – state-of-the-art book distribution.
The results indicate that the proposed method is capable of detecting different damage progression states.
The histopathological diagnosis takes two possible disease progression states into consideration: an inflammatory state and a fibrotic state [4, 5].
Alpha4-integrin shows progression state-specific regulation with upregulation in transgenic cells and downregulation in tumor cells (Table S3).
Given their association with apoptosis and their progression state-specific expression profiles, alpha4-integrin and BMP7 may represent constituents of switch mechanisms of carcinogenesis.
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