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This was not consistent with a cumulative progression scheme, in which tumors progress sequentially from stage 2 to stage 3 and end up progressing to stage 4. Next, we verified whether the level of genetic instability increased according to disease stage using two metrics, Global Genomic Index (GGI), and the number of breakpoints (nbBP) (as defined in the Materials and Methods section).
Most epithelial cancers follow a progression scheme in which initiated cells progress to adenomas to adenocarcinomas and metastasis, accumulating genetic alterations in a stepwise manner during progression [6].
A number of recent molecular-based studies support modification of this general progression scheme.
Perhaps prostate cancers derive from a more homogenous cell population, giving rise to a more homogeneous progression scheme.
However, no clear cut results were proposed ascertaining the existence of a molecular progression scheme between early carcinoma (stage 1), invasive (stage 2 and 3) and metastatic (stage 4) CRC.
The end point progression scheme we presented (Martin et al. 2009a) included aggregation of prolifera tive, preneoplastic, and neoplastic lesions for the development of predictive signatures from in vitro data coming from the ToxCast research program (U.S. EPA 2008a).
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The two studied disciplines show different progression schemes: most (63.9%) of T&F events have stopped progressing since 1993±8 years while all swimming events were progressing until 2009 (Fig. 1).
Several instances of the proposed NoC were implemented with various inter-routers links progression schemes combined with very simple router architecture and efficient client network interface (CNI).
Borrowing heavily from the four-stage progression they outline, we adapt this scheme here to describe agriculture in general and present attributes of each developmental stage.
To study the progression process, time schemes have been proposed for studying the process of colorectal cancer based on extensive clinical investigations.
The idea behind so-called in-work progression – the most ambitious scheme of its kind in the world, but as yet untested – is that by providing coaching and support, low-paid workers can be helped to find more or better-paid work, so making them less reliant on wage top-ups.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com