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Kastritis et al. reported that abnormal FLC ratio was one of the most significant factors for progression, reporting that the median TTP in the FLC ratio ≥ 8 arm was 55 months versus 73 months in the FLC ratio < 8 arm (P < 0.005).
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Median time to progression reported in one study was 6.3 months (Kim et al, 2002).
Consequently the differences in disease progression reported in this cohort may underestimate the discrepancy in the community.
Emergency physicians with job opportunities outside the health-care sector [ 23] and less salary progression reported higher ITL [ 26].
"PFS" was defined as the time from MBC diagnosis to first progression reported by physicians' standard practice or death from any cause, whichever occurred first.
Nevertheless, the difficulty in assessing disease progression reported by patients and their lack of knowledge regarding long-term treatment plans has implications for long-term management.
Median time to progression reported was 8 months (IQ range 5 11) for TEGAFIRI and 8 months (IQ range: 5 14) for TEGAFOX patients.
Furthermore, the tumour tends to be relatively radio-resistant, with local tumour progression reported with substantial doses of up to 70 Gray.
Progression-free survival was defined as the time from MBC diagnosis to the first progression reported by the physicians' standard practice or death from any cause, whichever occurred first.
A recent meta-analysis model of AD progression reported the absence of a significant impact of age; however, the distribution of the mean age in the model was narrow [ 40].
Although it is apparent from the literature that changes in terminal sialylation are of great importance during malignant transformation and cancer progression, reported data on the specific type of sialyl-linkage and the level of sialylation are very controversial and inconclusive.
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