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The median time to progression, progression free survival time, and overall survival time in the treatment groups was 14.9, 14.9, and 38.3 months, respectively.
In the DAdS group, those who received Diethylstilbestrol at the progression of disease, their TTP (PFS) was measured from randomisation to the first observation of disease progression (progression or death) after receiving Diethylstilbestrol.
Each model examined whether PCM scores were collected before or after disease progression (Progression), and also examined the proximity of PCM survey date to the date of the first disease progression (Proximity).
Radiographic endpoints included changes from baseline in total GSS, erosion and joint space narrowing scores and the proportion of patients with no radiographic progression (progression defined as change in GSS >SDC or >0).
Radiographic endpoints included changes from baseline in total GSS, erosion and joint space narrowing scores, and the proportion of patients with no radiographic progression (progression defined as change in GSS >1.5 for this specific reading campaign).
We in turn note that this post hoc analysis was not part of the original study design, was subject to false-positive results due to multiple comparisons, and used rough proxies for diabetes progression (progression to oral or insulin therapy).
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Secondary endpoints included time to progression, progression-free survival, overall survival, response rate, safety and toxicity.
bType of TDE refers to time to progression, progression-free survival, and event-free survival.
There was no difference in the rate of within radiation field progression, progression-free survival, or overall survival.
Two endpoints have been used in the study – the date of death (overall survival) and the date of disease progression (progression-free survival).
The primary endpoint of the study is overall survival and secondary outcomes, being time to progression, progression-free survival, objective tumor response, and disease control.
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