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Recent technological advances in genetics and epigenetics offer a better understanding of the underlying epigenetic alterations during initiation and in the progression process of the human tumors.
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The fact that the log2 ratio average of aberrant regions reflects the ratio of tumors can help us follow the progression process of tumor cells [ 6].
Based on the above results, we asked whether there are associations between the inflammatory chemokines CCL2 & CCL5 and the inflammatory cytokines TNFα & IL-1β in patients representing different stages along the progression process of breast cancer.
Thus, the early diagnosis of GA is crucial for slowing down the malignant progression process of gastric mucosa.
For instance, as these multivariate longitudinal data are actually temporal realizations of an underlying disease progression in different dimensions, how to leverage our knowledge of the disease progression process to fuse the data is a challenge.
Although, many of the key gene-silencing events occur very early during the premalignant stages of tumor progression, the process of epigenetic gene silencing continues through the entire progression of human cancer, where DNMT1 plays the predominant role as the maintenance methyltransferase.
Genes found to be differentially expressed between normal colon, adenoma, and carcinoma can be used as markers of the progression process.
When performing a simulation study, we should examine the event generation process, which might be suited to the situation of the disease progression process [ 22].
As the patients were 6 years older at follow-up, some progression of the degenerative process of the rotator cuff might have been expected (Panni et al. 1996).
Thus, RA-induced expansion of cells may represent a discrete step of the tumor progression process once cells have lost RAR function.
In the case of cancer, mutations are well documented to arise in key oncogenes and critically important tumor-suppressor genes as part of the disease progression process.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com