Detection of visual field progression requires understanding of variability, the magnitude of change that is considered clinically significant and the number of visual fields required to detect this change with adequate statistical power.
Conversely, a high degree of variability in disease progression has been reported among series.
The TTE approach is well-suited to assessment of screening and intervention of neurodegenerative diseases because of the need to account for the high degree of variability in disease progression and potential differentiating risk factors.
Additionally, although we used multiple absolute and relative definitions of CAC progression, interscan variability may have affected the CAC progression outcomes in our study.
The age at initial presentation and progression of hearing loss has shown variability between DFNA2 families, reinforcing the phenotypic heterogeneity of the disease.
Since there is variability in progression of HIV infection, not taken into account in our analysis, it is possible that some of these individuals could already have been infected at the time the indicator disease was diagnosed.
However, there are no single genes strongly predictive of individual neuropsychiatric syndromes, while functional and structural brain changes unique to specific symptoms may reflect variability in progression of the same pathological processes.
Therefore, it is important to clarify the role of variability in SBP in the progression of diabetic nephropathy.
Although variability in eGFR in CKD progression may have not been well studied, the concept of variability has been applied to different physiological markers in medicine and is supported by various biological mechanisms.
Samples in both series are linked to their time of eruption and vent of origin to allow a spatiotemporal account of geochemical variability throughout the progression of Surtsey's eruption, from both whole rocks (melt + crystals +/− inclusions) and glass (melt now preserved as glass in tephra, but having been subjected to some fractionation during the eruption) perspectives.
These findings highlight the variability in the progression of IPF, and may explain, in part, the difficulty in obtaining significant and reproducible results in studies of therapeutic interventions in patients with IPF.
