We recently demonstrated that AURKA, together with TPX2, drives 20q gain-associated adenoma-to-carcinoma progression based on the correlation of AURKA DNA copy number status to mRNA and protein expression levels combined with its functional effects on cell viability, anchorage-independent growth and invasion (Sillars-Hardebol et al, 2012).
Met expression does appear to increase during prostate disease progression, but the correlation of Met expression with Gleason grade has been tenuous.
In the first set of experiments we analyzed the kinetics of TB progression and addressed the correlation between TB progression, mycobacterial multiplication, and lung tissue pathology in (A/SnxI/St) F2 mice.
This correlation was still significant when the UPDRS or PSPRS, as proxy measures for general disease progression, were partialled out of the correlation.
Diabetes does not influence the bilateral and radial nature of progression, but reduces the correlation between distal sites within an artery.
It is well known that p53 acts as an important regulator in modulating epithelial-mesenchymal transition (EMT) that is implicated in tumor progression, metastasis, and the correlation of poor patient prognosis [ 71, 72].
Secondary objectives include the association between CD8+ T cell counts and progression free survival, the correlation of CD8+ T cell counts quantified by immunohistochemistry and flow cytometry, local tumour control and recurrence patterns, survival, radiogenic treatment toxicity and postoperative morbidity and mortality.
Although p-Stat3 expression was not an independent prognostic factor for either overall survival or progression-free survival, probably because of the correlation with other clinicopathological factors in our study, it was interesting to observe that the hazard ratio was the highest in the significant prognostic factor by univariate analysis (data not shown).
RhoGDIβ is implicated in cancer progression, however, reports have presented contradictory evidence as to the nature of the correlation between cancer progression and RhoGDIβ expression level [ 44].
CD117 might also be thought to play a role in tumoral progression, as suggested by the correlation of cytoplasmic CD117 staining and higher histological grade, by facilitating neoplastic cell mobility and binding of fibronectin.
Susceptibility to murine cytomegalovirus retinitis during progression of MAIDS: correlation with intraocular levels of tumor necrosis factor-alpha and interferon-gamma.
