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This diabetes-induced alteration in the functional organization of the capillary/arteriolar unit is likely to impair its ability to efficiently and effectively regulate blood flow and thereby, may contribute to the progression of sight-threatening complications of diabetic retinopathy.
These findings suggest that basement membrane thickening is not just an epiphenomenon of the diabetic state, but may be instrumental in the progression of sight-threatening diabetic retinopathy.
Patients who were well informed regarding their glaucoma status and low risk of progression to sight loss were more accepting of the GSMS.
Younis et al. reported that patients using insulin were at higher risk of progression to sight-threatening diabetic retinopathy in the longitudinal Liverpool Diabetic Eye Study [ 42].
Tight control of blood glucose and blood pressure reduces the risk of progression towards sight threatening disease [ 36] and visual outcome in patients with diabetes is related to regular eye examination [ 22].
Glaucoma comprises a wide spectrum of disease ranging from very early disease with low risk of progression to significant sight loss, to those at a more advanced stage with a high risk of progressing to advanced visual loss.
The authors hypothesized that the increased visual impairment with long-term follow-up is partly a consequence of sight threatening PCG progression or ocular-comorbidity that can occur at any point in the follow-up period [ 73].
Critical investments like these are essential to arrest the progression of the disease and prevent loss of sight.
Line-of-Sight Networks.
This results in line-of-sight deposition.
Direct line-of-sight.
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