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In the case of formaldehyde, however, the progression of responses is clear, with human studies showing that for most individuals, odor perception generally precedes sensory irritation.
Importantly, Haber's Law is not relevant for formaldehyde-induced irritation effects, an observation confirmed by Andersen et al. (2008, 2010) with toxicogenomic data demonstrating that continuing exposure at doses <2 ppm do not result in a progression of responses.
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Progression of response to systemic inflammation induced by endotoxemia in immune cells has been described at the genomic level [ 16, 30].
As an alternative to sequential progression of response dynamics from linear to adaptive, a hybrid response could result from combining the outputs of two distinct systems, one with an adaptive and one with a linear response.
Macrophage phenotype is dynamic throughout the course of these processes, and the balance between phenotypes is instrumental in the timely progression of these responses from injury to successful healing.
The persistence of activated myofibroblasts during the progression of fibrotic responses may be accounted for by resistance to apoptosis.
MHC molecules are required for antigen recognition by lymphocytes, ultimately leading to activation and progression of immune responses.
It has been suggested that leptin specifically impairs the proliferation of regulatory T-cells, thereby promoting the onset and progression of autoimmune responses 12, 24– 24.
During the progression of inflammatory responses, soluble isoforms of the leukocyte recruitment adhesion molecules are shed from cell surfaces and accumulate within the circulating blood plasma [ 10].
B10 cells therefore emerge during chronic inflammation in mouse models of inflammatory bowel disease, where they suppress the progression of inflammatory responses and ameliorate disease manifestations.
In addition, both SP and NK1R are expressed in microglial cells, which are involved in initiation and/or progression of immune responses within the CNS [ 17].
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