During the progression of OA, the endogenous HA in the joint is depolymerized from being of a high molecular weight (6500 10,900 kDa) into a lower molecular weight (2700 4500 kDa), which consequently diminishes the mechanical and viscoelastic properties of the synovial fluid in the affected joint [18, 20].
Thus, individuals enter this compartment through rapid progression of recent infection or endogenous reactivation of latent infection.
The ability to suppress TLR signaling might be beneficial in RA since TLR signaling may contribute to the progression of RA mediated by endogenous TLR ligands [ 11].
Surprisingly, GNPs transplanted into the cerebellum of preataxic Hq mice reduced neurodegenerative changes, slowed the progression of ataxia, and stimulated endogenous neurogenesis from a previously unsuspected niche in the cerebellar leptomeninges.
These findings indicate that knockdown of endogenous DBZ delays the progression of sequential events leading to oligodendrocyte differentiation.
This notion is supported by evidence that castration (removal of endogenous testosterone) can inhibit PCa progression [ 6, 105], while administration of exogenous testosterone can promote PCa progression [ 106, 107].
With increasing age and progression of articular cartilage degeneration, the expression level of endogenous BMP-7 decreases [ 6], suggesting that a decrease in BMP-7 may play an important role in the progression of cartilage degeneration.
Epidemiological and experimental evidence indicates several atheroprotective effects of endogenous estrogen, which intervenes from atherosclerosis progression and inflammation.
A woman's level of endogenous estrogen may be important in the progression of BBD to invasive breast cancer.
Oxidative stress has been implicated in the progression of various diseases, which may result in the depletion of endogenous antioxidants.
