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In addition, ROR1 is critically involved in progression of a number of blood and solid malignancies.
Bcl-2 has been implicated in the development and progression of a number of cancers including colorectal cancer.
DJ-1 (PARK7) is a multifunctional protein linked to the onset and progression of a number of diseases, most of which are associated with high oxidative stress.
The ErbB family of receptor tyrosine kinases is involved in initiation and progression of a number of human cancers, and receptor activation or overexpression correlates with poor patient survival.
Many studies have demonstrated that hypovitaminosis D is widespread through the Western world leading to postulations that it is associated with the development and/or progression of a number of conditions ranging from neurological disorders through to hypertension, type 1 diabetes, kidney disease and cystic fibrosis [1].
This degradative pathway has been implicated in the progression of a number of diseased states including cancer.
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This aspect is particularly important in the light of a recent publication on T. b. rhodesiense HAT reporting the poor association between disease progression, the levels of a number of cytokines and patients' neurological manifestations [51].
Modulation of HIF-α has been mechanistically linked to the progression and severity of a number of disease processes, including cancer and inflammatory diseases (Semenza, 2012).
Consistent with their role in tumor progression, high levels of a number of MMPs have been shown to correlate with poor prognosis in human cancers [ 9- 11].
However, despite its tremendous contribution towards understanding the establishment, progression and control of a number of diseases in general and tuberculosis in particular, the lack of fully annotated guinea pig genome sequence as well as appropriate molecular reagents has severely hampered detailed genetic and immunological analysis in this animal model.
The role of steroids and their receptors in breast cancer progression was the focus of a number of presentations.
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