This is a useful method when the pattern of change over time may be influenced by the course of progression of a health condition.
The progression of a premalignant condition to a lethal malignancy is thought to involve an accumulation of mutations in genes that regulate cellular proliferation, survival, and differentiation [ 1, 2].
It is differentiated from systematic and longer-lasting time-related changes in task performance due to practice, learning, developmental growth, or to remission or progression of a clinical condition or disease.
Thus, they potentially offer an opportunity for intervention at earlier stages in the progression of a patient's condition.
Focus groups also suggested that we should give the questionnaire a logical progression, mimicking the traditional progression in medical management of a condition.
Many studies have demonstrated that hypovitaminosis D is widespread through the Western world leading to postulations that it is associated with the development and/or progression of a number of conditions ranging from neurological disorders through to hypertension, type 1 diabetes, kidney disease and cystic fibrosis [1].
We present a case demonstrating a natural progression of the condition and highlight the importance of having a high index of suspicion of diaphragmatic injuries in the trauma setting.
This syndrome must be considered even in absence of all typical symptoms to prevent the progression of a potentially life threatening condition.
In most cases, due to a deterioration of health status or a progression of the medical condition, the burden of living outweighed any associated benefit for the patient without any perspective or reason for life.
A number of indices have been developed typically using grading or scoring designed to identify increasing severity or progression of the condition, but traditionally with a focus on only one aetiological factor.
