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For the first patient group (n = 16) EDSS progression, number of steroid interventions and relapse rate two years before initiation of treatment were assessed retrospectively and compared to the first two years after start of treatment.
Additional end-points included the time to 12-week confirmed disability progression, number of Gd+ lesions, and number of new or enlarging T2 lesions, all at 2 years.
Furthermore, we analysed the association of breast cancer subtypes with brain as first site of disease progression, number of BM, time to development of BM (<24 months vs >48 months), and development of carcinomatous meningitis.
Finally, application of a random forest model (Michaelson et al., 2010; Francesconi and Lehner, 2014) that simultaneously considers developmental progression (number of somites) and genotype also did not enrich for trans-eQTL.
A pre-specified integrated analysis of DEFINE and CONFIRM was conducted to assess DMF's effects on end-points including annualized relapse rate (ARR), proportion of patients relapsed, disability as measured by 12-week confirmed Expanded Disability Status Scale (EDSS) progression, number of gadolinium-enhancing (Gd+) lesions and number of T2 lesions, at 2 years [ 6].
Secondary endpoints were rate of remission, primary progression, number of patients receiving alemtuzumab, therapy-related mortality, EFS and OS, calculated as the time from registration to the first reported event (PRO, initiation of salvage therapy, additional (unplanned) treatments, relapse or death of any cause) or censored at the most recent assessment date.
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Rather than doing any of these things, the Tef will be based on three crude metrics: student retention and progression; the number of students in paid employment after graduation; and scores on selected items of the National Student Survey.
Clinical progression, total number of paws affected and peak severity did vary widely between mice.
During disease progression, the number of hypermethylated genes increased to 5,465 in the late leukemic disease stage.
These data suggest that with disease progression the number of mesenchymal progenitors increase independent of the site of inflammation.
For the regression of survival against time to progression, the number of patients in the study was used as weights.
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