Thus, bone resorption markers, especially ICTP, could be a good indicator of the progression and multiplicity of disease, and it could help in the follow-up and in the monitoring of therapy for bone metastasis from lung cancer.
With a likely scenario in vivo being low-level exposure to various stimuli, we suggest that such networks facilitate progression from a multiplicity of initiation points to a similar end-stage hypertrophic phenotype.
Although multiplicity and progression of early adenomas were reduced by genetic ablation of STAT3, loss of STAT3 at later stages promoted tumour progression and favoured the development of invasive carcinomas, resulting in a significantly shorter survival.
In contrast, mice treated with SRL or CsA+SRL had decreased tumor multiplicity, size, and progression compared with vehicle-treated mice.
Effects of p190B deficiency on tumor latency, multiplicity, growth, preneoplastic progression and metastasis were evaluated.
Using AOM as a tumor initiator and the microbiota to trigger chronic colitis in genetically susceptible Il10−/− mice, we show that inflammation directly correlates with colorectal tumor multiplicity and enhances tumor progression.
We observed a clear distinction between increased tumour initiation (increased ACF multiplicity) and no effect on progression to adenoma and reduced tumour growth (demonstrated by no difference in AOM-induced tumour incidence and reduced tumour size) in IL-4Rα-null mice compared with WT animals.
Other factors, such as risk behavior, plasma HIV-1 RNA levels, and co-infections, can also affect both multiplicity of viral transmission and disease progression.
The rate of disease progression, as well as the cyst morphology and multiplicity, varies according to the specific disease and mutations.
