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Fast progressors were defined as patients exhibiting above average rates of ALSFRS decline (median: 0.77 units/month [30]) or MMT decline (mean: drop of 1%/month [29]), and slow progressors were defined as patients exhibiting smaller than average longitudinal decreases in both of these clinical progression measures.
Individual pain or structural progression measures were examined in 88 studies; 52 studies examined multiple features.
Descriptive statistics were calculated to characterize the population for all variables of interest, including baseline demographics, baseline hip radiographic features, and HOA progression measures.
These findings suggest HbA1c may exhibit differential associations with CAC progression measures, indicating a complex association of HbA1c with multiple markers of subclinical atherosclerosis and potentially cardiovascular events.
Effect modification by race was evaluated but was not statistically significant for any of the CAC progression measures (interaction P values >0.35).
The two biggest obstacles are the lack of compelling, pediatric‐specific biomarkers and ill‐defined or absent pediatric disease progression measures.
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In this paper, we consider the problem of predicting disease progression measured by the cognitive scores and selecting biomarkers predictive of the progression.
The ALS subjects were prospectively followed for one year to define factors that influence the rate of disease progression, measured by rate of change in percent predicted forced vital capacity (%FVC) and the ALS functional rating scale (ALSFRS) score.
The HAS and MADRS showed non-significant correlation with the rate of initial disease progression measured by the onset-admission duration (p-values 0.439 and 0.965 respectively).
Both anxiety and depressive symptoms were non-significantly correlated with the rapidity of symptoms progression measured by the duration between symptoms onsets and admission times which are possibly explained by the exclusion of GBS patients with severe motor disabilities that may exhibit more rapid disease progression.
For cell cycle progression measured by FACS analysis, cells were fixed in 70% ethanol and stained with propidium iodide (Sigma).
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CEO of Professional Science Editing for Scientists @ prosciediting.com