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We suggest that a more thorough understanding of ITH would be helpful to develop treatment strategies using this concept as a progression marker of metastatic and recurrent tumors.
Frantzi et al. described urinary histone H2B and Zinc-finger 335 (NIF-1) as a potential progression marker for BCa.
Expression of the melanoma progression marker MCAM was also analysed relative to PAX3.
Gene expression profiling of human melanoma biopsies and cell lines indicated ETBR as a tumor progression marker associated with an aggressive phenotype [21], [22].
ABCB5 is also indicated to be a metastatic melanoma progression marker, and it is suggested that this transporter has a role in the regulation of progenitor cell fusion [9], [16].
Our data suggest that this single molecule can modulate NHERF localization and, independently, act as a key orchestrator of apical cell morphology, thereby lending mechanistic insights into its multiple roles as a polarity regulator, tumor progression marker, and anti-adhesin.
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Rio, J. et al. Disability progression markers over 6 12 years in interferon-beta-treated multiple sclerosis patients.
To evaluate the proposed method, we use the popular Parkinson's progression markers initiative (PPMI) database.
I have contributed to the critical studies on these diseases, including Parkinson's Progression Markers Initiative (PPMI) and Alzheimer's Disease Neuroimaging Initiative (ADNI).
The applicability of the proposed methodology has been demonstrated using 831 T1-weighted MRIs obtained from Parkinson's Progression Markers Initiative (PPMI) database.
Results of the study, called the Parkinson's Progression Markers Initiative, are expected to facilitate the testing of new drugs that may slow or stop the disease in its tracks.
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