In keeping with the potential of miR-101 to regulate autophagy and ovarian cancer progression, it is to be mentioned that its target RAB5A was shown to be upregulated and to promote cell proliferation in ovarian cancer [ 112].
Taking together the previous published reports of Hakai during tumor progression, it is increasingly apparent that further investigations of its physiological and pathological functional role would lead us to a novel molecular target for cancer treatment.
Despite increasing knowledge of the processes underpinning liver disease progression, it is still not possible to predict which patients will progress and which will experience minimal fibrogenesis.
Given the generally slow rate of CKD progression, it is possible that longitudinal analysis may differentiate between stable and progressive CKD and better delineate this association.
Because few studies have investigated the association between baPWV and CAC progression, it is unclear whether baPWV can be used to identify subjects with progressive subclinical CAC.
Having thought about career progression it is just as important to communicate: ensure that the primary marketing document, the CV, reflects where you are headed.
Additionally, because TGFβ induces formation of cancer-associated fibroblasts (CAFs) to promote cancer progression, it is not surprising that Smad7 can block this process (Li et al., 2013).
However, since delamination and matrix-cracking damage modes are known to co-exist and fuel each other's progression, it is desirable to investigate extension of these models for multiple damage modes.
In an era of emerging new therapies aiming to modify disease progression, it is critical to have a biomarker that enables the monitoring of disease course and effects of therapeutic interventions at the cellular level.
As for the speed progression, it is the principal reason for the negative attitudes towards shadowing in this study, because of the speed being too fast for certain participants to keep up with.
Though extensive work has been done analyzing the mechanotransductive signals involved in tumor progression, it is still not clear whether the stiffness induced changes in cancer cell behavior is conserved across the invasive/aggressive phenotype of cells.
