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Statins and spironolactone may decrease the rate of CKD progression independently or in addition to RAS inhibition.
For example, several glycolytic enzymes, deregulated in cancer, contribute to tumor progression independently from their canonical metabolic activity.
Thus, lung tissue inflammation can contribute to disease progression independently of Mtb load.
Altogether, these in vitro and in vivo data demonstrate the differential expression of ARG1 and ARG2 between various stages of PCa progression, independently of the HR status.
In this model, patients in the lowest tercile of RRM2 continued to have the lowest risk of progression, independently of RRM1 levels.
Studies have demonstrated that HIV-1 DNA load in peripheral blood mononuclear cells (PBMC) have a predictive value for disease progression, independently of CD4 counts and plasma viral load.
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A large number of experimental studies have demonstrated that chronic nephropathies share common pathogenic mechanisms that contribute to renal disease progression, even independently of the original etiology.
HIV-1 subtypes can vary in disease progression rates independently from viral load as well [30].
The risk of disease progression is independently associated with the serum HBV DNA level [ 25].
Although initially playing a compensatory role, the changes become detrimental with time, favouring disease progression and independently predicting and contributing to cardiovascular complications and death of treated HF patients.
These observations indicate that the disease progression is independently associated with an increase in CTv of AS, and CTv in AS reflects the tumor burden of neoplastic plasma cells.
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