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Despite the substantial progression in understanding WBD, many questions remain unsolved, mainly those concerning the mechanisms controlling processes such as: (i) the fungal switch from biotrophism to saprotrophism; (ii) the drastic phenotypic alteration of cacao during disease development and (iii) the death of infected tissues.
Methodical review of the relevant studies is presented following a systematic approach, to assess the gradual progression in understanding of the practical system.
It is clearly important to chart this progression in understanding and acceptance, and hence, the literature is reviewed on a historical basis, with the aim of appreciating what CSR has meant in the past and what it means today.
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Vascular endothelial dysfunction plays a major role in the pathogenesis of metabolic and cardiovascular disease [30], [31], [32] and further characterisation of the vascular endothelium prior to and during disease progression could prove useful in understanding risk factors, disease mechanisms and identification of potential therapeutic intervention strategies.
An understanding of growth dynamics of tumors is important in understanding progression of cancer and designing appropriate treatment strategies.
These examples of Rho protein expression and activation in aggressive cancers illustrate the importance of these molecules in understanding progression to a metastatic phenotype.
Future studies evaluating TNF-α and MMP-9 on fresh or frozen tissue utilizing western blotting or real time PCR over the course of disease progression may be helpful in understanding the role of TNF-α and MMP-9 as potential early biomarkers for IBD.
In some instances someone (a physician, nurse navigator, or secretary) would help patients understand which physicians or clinics provided each treatment and aid patients in understanding their progression through a variety of caregivers and settings.
Advances in animal models of retinoblastoma have accelerated research in this field, aiding in understanding tumor progression and assessing therapeutic modalities.
Biomimetic cell culture systems that recreate tumor microenvironments are necessary in understanding the progression of cancer cells in cell-to-cell interaction and in cell-to-extracellular matrix interaction.
He is a cancer epidemiologist with a research focus in understanding cancer progression.
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