Thus, besides the well-studied modulator gene estrogen receptor 1 (ESR1, the ERα encoding gene; as a positive result in this study), in the list of candidate modulator genes we exploratorily included 9 more candidate genes that were recorded as association with "breast tumor progression" in the knowledge-based database Ingenuity Pathway Analysis (Qiagen Inc).
In recent years, progressions in our knowledge of cell biology demonstrated that the study of cell behavior cannot exclude signals deriving from the environment in which cells are located.
3. Maturation: Does the outcome measure allow for natural progression in learning and knowledge?
We believe this opens up new possibilities for estimating quantitative dose- and time-dependent responses in toxicology and in disease progression using knowledge of molecular mechanisms.
Poor reporting wastes many hours of researchers, clinicians and patients' efforts and is more likely to result in duplication of research efforts rather the efficient progression of knowledge and improvements in clinical practice.
As Philaretus, Geulincx accepted the progression in Cartesian metaphysics from doubt to knowledge and from knowledge to God and affirmed the dominant role of the will in forming judgments.
Lastly, whereas the UK and Australian guidelines provide competency frameworks (allowing assessment of progression from knowledge to performance in practice [ 38]), our final list is a combination of knowledge, competencies and actions, with no performance items.
The report highlighted a number of problems, including decision-making (delay in progression to cricothyroidotomy), knowledge gaps (not understanding how available equipment worked), system failures (specific equipment not being available), and technical failures (failure to site a cannula in the airway).
This more recent iteration of RoomQuake introduces a knowledge-building progression in which a series of challenges is presented to students where they must determine the characteristics of earthquakes using a variety of tools including seismographs, tape measures, and stop watches.
Knowledge of longitudinal progression in mild Alzheimer's disease (AD) is required for the evaluation of disease-modifying therapies.
