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It is postulated the arrythmogenic progression in cases of IVMS aneurysm relates to the stretching of this conducting system at the base of the aneurysm.
It has also been shown that the GSTM1 positive genotype evidenced a significantly better time to progression in cases of advanced gastric cancer being treated with FOLFOX [ 20].
We have also shown that the Glutathione S-transferase M1 (GSTM1) positive genotype evidenced a significantly better time to progression in cases of advanced gastric cancer being treated with FOLFOX [ 18].
Therefore, in future experiments, we should carefully determine the relationship between the TFRC expression time course and disease progression in cases of OSCC that have developed from dysplasia as well as the effectiveness of the anti-TFRC antibody against OSCC.
Whether or not nodal status can now be used routinely to predict better outcome in cases of pathological negative nodes or indicate a high risk of early recurrence and disease progression in cases of pathological positive nodes needs to be validated in additional studies.
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Taken together, these data suggest the existence of a cross-talk between the nuclear and the mitochondrial genome that slows down cell cycle progression in case of mitochondrial defects.
Patients who were not submitted to surgery were classified as progression in case of tumour marker raise after the plateau.
Patients may continue study medication beyond disease progression in case of clinical benefit, as long as this is judged beneficial by the investigator.
Patients were treated after allo-SCT at biological progression (before appearance of CRAB symptoms) or, if not preceded by biological progression, in case of EMR (biological and imaging follow-up).
Progression-free survival (PFS) was defined as the time between the end of therapy and the time of disease progression in case of tumour recurrence, or between the end of therapy and the end of follow-up in case of clinical remission (CR).
The two analyses conducted (the one conducted in the joints defined as abnormal by a score above 0 and the one by a score above 1), showed a trend or statistical significance suggesting more frequent structural progression in case of persistent synovitis.
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