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36 Our analysis used Kaplan-Meier data, and explored a variety of parametric distributions to determine progression hazard for cryotherapy.
In univariate analysis, hK6-positive patients had a significantly increased risk of disease progression (hazard ratio=1.71) and death (hazard ratio=1.88) (P<0.05).
The median progression-free survival in the 3- and 12-month groups was 21 and 28 months, respectively (P=0.0023 by adjusted Cox model analysis), with a 3- vs 12-cycle progression hazard ratio of 2.31.
Multivariate Cox regression analysis revealed that the expression signature of S100A8-correlated genes was a strong predictor of disease progression (hazard ratio = 15.225, 95% confidence interval = 1.746 to 133.52, P = 0.014).
Figure 1 depicts the OS curve for both groups, showing a nonstatistically significant trend of improved survival for patients continuing the drug after progression (hazard ratio [HR] 0.87, 95% CI 0.58 to 1.32).
The results have been reported recently and clearly showed that 4 Gy was inferior to 24 Gy in terms of time to local progression (hazard ratio of 3.4; 95 confidence interval [CI] 2.09-5.55, p < 0.0001).
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The progression hazards increase monotonically with age in all categories and are highest for the obese category followed by overweight and normal at all ages.
As BRCA1 levels increased, the probability of response increased (Odds Ratio [OR], 1.09: p = 0.01) and the risk of progression decreased (hazard ratio [HR], 0.99; p = 0.36).
Furthermore, analysis of the time course of these functions allows scientists to study the time course of the progression of hazard and the decline in survival for these patients.
For the progression-free hazard, the number of observed high and low individuals was 87 and 88, respectively, and the number of predicted high and low individuals was 83 and 92, respectively.
Univariate analysis revealed that MET FISH-positivity was the most significant independent factor associated with a high risk of progression and death (hazard ratio, 3.83 (p = 0.0008) and 2.25 (p = 0.03), respectively).
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