Sentence examples for progression has remained from inspiring English sources

Despite a clear pathogenic role for mutant huntingtin, understanding huntingtin expression during the presymptomatic phase of the disease or during disease progression has remained obscure.

Thus, the pressing question as to the biological basis of cervical cancer progression has remained unresolved.

Thus, the pressing question as to the biological basis of cervical cancer progression has remained unresolved, hampering the development of novel therapies and prognostic tests.

Despite these important discoveries, a detailed view of the biological pathways that mediate AMD development and progression has remained obscure.

While the Myc oncogene has long been known to be crucial for tumor progression [ 47], its role in promoting metastatic progression has remained unclear.

While the sequential accumulation of various genetic changes in hepatocarcinogenesis has been extensively studied, the contribution of epigenetic alterations to HCC development and progression has remained relatively poorly understood.

Although there is substantial evidence that IL-8 is increased in breast cancer, the mechanisms by which IL-8 contributes to breast cancer progression have remained virtually unknown.

However, not all patients with the same ERα status manifest the same cancer progression or response to hormone therapy, and individual variations in breast cancer progression have remained an issue of particular concern.

Besides these observations, the potential interconnections between cell fate choice and cell-cycle progression have remained largely unstudied due to the lack of molecular tools for investigating cell-cycle mechanisms in pluripotent cells.

In contrast to chronic myeloid leukaemia, the molecular mechanisms leading to Ph- MPN progression have remained unclear until the recent finding of the V617F JAK2 mutation in most of Polycythemia Vera (PV) and half of Essential Thrombocytosis (ET) and Primary Myelofibrosis (PMF) cases ([ 3], see for review [ 4]).

To date, the functional importance of ALDH enzymes in prostate carcinogenesis, progression and metastasis has remained elusive.