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But what Mr. Reed sees as logical and smooth progression has become anything but.
THE QUESTION Because no cure for Alzheimer's exists, preventing or delaying its symptoms and progression has become the focus for those with the memory-robbing disorder.
Overall the role of CHD4 in DNA repair and cell cycle progression has become increasingly well described over the last few years.
In addition, tumor development and progression occur as an interaction between tumor cells and their stromal environment [for review: [ 35, 36]], and the concept of epithelial to mesenchymal transition (EMT) as a driver of tumor progression has become more important in recent years [ 37, 38].
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Therefore, identifying the corresponding genes and exploring the regulatory mechanisms involved in tumor progression have become critical issues.
Traditionally, hypoxia has been considered a marker of tumor progression, and has become a central issue in tumor physiology and treatment.
Although epidemiological studies have to determine the risk of disease progression, it has become obvious that chronic inflammation in NASH is a trigger that can lead to the development of HCC – even in the absence of cirrhosis in a yet poorly defined subset of patients [ 7].
Recently, more and more attention has been focused to COPD patients complicated with SMD, but how to slow down the progression of SMD has become a key point to reverse COPD.
Because of its essential roles in chromosome segregation and mitotic progression, the APC/C has become a therapeutic target for the treatment of multiple neoplastic diseases (Bassermann et al. 2014).
Over the past decades, the importance of intra-articular inflammation in joint pain, joint effusion and progression of cartilage damage has become increasingly appreciated [ 2, 33], as has the usefulness of synovial fluid biomarkers for monitoring disease progression or therapeutic response [ 5].
More importantly, Botswana's progression of economic growthmanship has become the envy of its neighbors, as well as a source of inspiration, which they should consider emulating.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com