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The results obtained from several studies have shown that the progression from a single normal cell to a fully malignant phenotype requires both the activation of oncogenes and the inactivation of tumour suppressor genes.
There, we found an unusually fulminant progression from a single small osteolytic lesion to widely disseminated metastases in multiple organs during hormonal treatment for oocyte harvest before the planned chemotherapy.
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To summarize, our analysis established a link between human phenotypic disease network and protein evolution, which will definitely help in understanding human monogenic disease etiology and the underlying mechanism of disease progressions from a single gene.
Zhang et al. [26] synthesised progression probabilities from a single source [44], although it is not transparent how progression probabilities were arrived at.
The model by Weimer et al. [30] used disease progression data from a single study of 134 patients on cholinesterase inhibitors [45].
The chorus is supported by vocals from a choir, a four-chord progression and a single guitar note, played by Rodgers.
The simulation study of Sprouffske et al. (2011) compares estimates of tumor progression that use multiple samples from a single tumor/patient with those obtained from cross-sectional samples from many independent tumors and finds that the cross-sectional estimates can be quite misleading due to the heterogeneity of paths to tumorigenesis seen in tumors.
The turbine in this study is the product of design progression from a commercial nozzleless unit to a single-entry variable geometry and consequently to a twin-entry unit.
We proposed that this represented intra- and intermolecular epitope spreading and was an indicator of disease progression, in a manner analogous to the conversion from a single to multiple islet autoantibodies in the progression to T1D [ 41, 42].
We assessed the time-influencing clinical-pathological factors for biochemical progression of an equal series of patients from a single institution.
The tumour growth rates were estimated as clinical rates of progression (i.e., the time elapsed from a single distant metastasis until dissemination).
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CEO of Professional Science Editing for Scientists @ prosciediting.com