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The bottom line is that although a "step-by-step approach," "from the safest to the riskiest," is prudent, a good history and clinical judgment are required to ascertain what, exactly, would constitute such a progression for a given patient.
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The bolding denotes the progression of a given case.
Statistical modeling can be used to find the best weighted combination of items for measuring progression in a given population.
It can act as an integrating biomarker by detecting chemopreventive activity even when the mechanism for a given progression pathway is unknown, or when multiple pathways exist.
For a given dose range, the onset and progression of toxicity are observed at different time points for different compounds.
Similarly, a chemotherapeutic protocol is designed for a given population while simultaneously accounting for control of tumor progression and side effects due to doxorubicin.
The risk of quadriplegia for a given cervical spine management strategy depends on its efficacy in reducing progression.
Announcing the new venture, Studio Ramsay described itself as a "next-generation multimedia production company, and the natural progression for Ramsay given his vast television knowledge and production capabilities".
Multiple regression analysis was applied to determine the predictive value of a given parameter for the progression of renal failure (final serum creatinine).
Finally, identification of patients at risk for progression remains challenging given the discriminatory power of current models, highlighting the need for better measures of AF disease progression.
Crutch weaning commences 1 month (sooner with the newer locking bolt) following osteotomy and, if radiographs confirm callus formation, permission for progression of activities given.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com