Sentence examples for progression efforts from inspiring English sources

In an effort to suppress tumor cell malignant progression, efforts have been made to develop agents capable of inhibiting inhibit Met-induced EMT, including specific Met tyrosine kinase inhibitors, HGF antagonists that interfere with HGF binding to Met, and antibodies that prevent Met activation and/or dimerization.

Given the important role of DNA methylation in tumor initiation and progression, distinct efforts have been made towards the use of DNA methylation as a biomarker in cancer [3], [4].

Because miRNAs play a critical role in tumor formation, maintenance, and progression, intensive efforts have been made to develop miRNA-based therapeutic strategies for cancer treatment.

Because of the importance of HIF-1 in tumor development and progression, many efforts have been devoted to identify small molecule HIF-1 inhibitors for cancer therapy in pharmaceutical research, for example, as described in 9.

Given the established transcriptional roles of cyclin D1b in disease progression, future efforts will be aimed at defining the underlying mechanisms behind cyclin D1b-mediated transcriptional regulation and its role in both normal and malignant cellular processes.

The etiology of the condition has been debated for nearly half a century and the lack of knowledge about its cause and progression has stymied efforts to improve therapy and prevention.

Engagement of medicinal chemists early in the process can accelerate the progression of FBDD efforts by incorporating drug-friendly properties in the earliest stages of the design process.

This list is necessarily incomplete and serves here to indicate the progression of modeling efforts, with an increasing diversity of approaches available, a tendency to combine approaches in modeling workflows, and clear indications of an increasing number of successful case studies.

When Hrithik arrives, sporting a tuxedo jacket and jeans and that superb bouffant, he is obviously excited but also nervous about an Indian movie with an Indian star trying to penetrate the western mainstream .I keep hearing these terms like 'crossover' and 'first attempt', but I think it's all a natural progression of the effort to make a good film," he says.

A lot of attention has been devoted, in recent years, to signaling and transcriptional events that promote cancer insurgence and progression, in an effort to develop a large number of new, target-oriented anticancer drugs.

Given the possible role of aberrant DNA methylation in cancer initiation and progression, a significant effort has been directed to identify DNA methylation biomarkers in cancer and to use such markers to predict therapeutic responses and disease prognosis [ 4].