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Together, studies with different cdc48 mutant alleles reveal that Cdc48 is important for G1 progression during a normal cell cycle and under heat stress through different mechanisms.
These reports suggest that erlotinib may be active even in patients who demonstrated tumor progression during a prior gefitinib treatment.
For example, an enhanced potential for efficacy could arise if both the endogenous glia and neuron pathways are key to pathophysiology progression during a common intervention time window.
The Funnel-shape of the behavioral progression during a sequence plays an important role in a wider context of animal behavior: coping mechanisms and behavioral states.
A retrospective analysis of five patients with tuberous sclerosis complex yielded mixed results concerning tumor progression during a KD and in no case tumor regression was achieved [ 68].
A good-outcome group consisted of 27 therapy-responsive patients who showed disease regression and no signs of progression during a 3 year follow-up.
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The entire progression calculated by MELCOR successfully demonstrates the capability of MELCOR to calculate the SFP responses covering both thermal hydraulics and severe accident progression during an accident involving both loss-of-cooling and loss-of-coolant accidents.
In the original licensing application for the prototype fast-breeder reactor, MONJU, the event progression during an unprotected loss of flow (ULOF), which is one of the technically inconceivable events postulated beyond design basis, was evaluated.
Low CD1c + mDC counts were correlated with a high risk of rapid disease progression during EHI, suggesting a potentially important prognostic marker and a promising target for intervention.
Exemestane (EXE) is a steroidal AI (sAI) with modest androgenic activity, which was studied in a phase II trial after documented progression during treatment with an nsAI, and showed a clinical benefit rate (CBR) of 20-40% [ 4].
Inclusion criteria were as follows: men with mCRPC and documented disease progression during or after a docetaxel-containing regimen.
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CEO of Professional Science Editing for Scientists @ prosciediting.com