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These multifunctional pathways transmit signals that result in prevention of apoptosis or induction of cell cycle progression, depending on the cell type, and can cross-regulate one another [ 37].
These results suggest that activation of Wnt signalling leads to two distinct pathways to induce initial tumorigenesis or metastatic progression depending on the different transcriptional output of Wnt signal in a cell context dependent manner.
What are the impacts on you, your compensation, your progression, depending on the decisions that you make?
Among the 15 mRNAs found to be overexpressed, we focused on Immediate early gene X-1 (IEX-1) mRNA because of the recognized contribution of its expression to apoptosis or cell cycle progression, depending on the cell type and culture conditions.
It is remarkably heterogeneous both clinically and biologically, as there is a large variation in tumor progression depending on the age of the patient at the time of diagnosis and the tumor stage [1].
Particularly, M2 macrophages contribute to tumor progression, depending on the expression of NF-κB.
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Cell cycle progression depends on the activation of cyclin-dependent kinases (CDK), which act consecutively in G1 to initiate S phase and in G2 to initiate mitosis.
Thereafter, from dosages from one-quarter of WT to the WT-level, cell cycle progression depends on the ability to pass through G2.
However, the risk of infection with M. tuberculosis and progression to tuberculosis disease is influenced by host factors and especially risk of progression depends on the hosts' immune status, which may be reduced due to concomitant HIV infection, diabetes, and other underlying diseases [27], [28].
Therefore, we assume that the progression depends on the serum HBV DNA level, regardless of nucleoside resistance.
This finding indicated that the inhibition of tumour progression depends on the formulation of the compound and the route of administration.
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