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These multifunctional pathways transmit signals that result in prevention of apoptosis or induction of cell cycle progression, depending on the cell type, and can cross-regulate one another [ 37].
These results suggest that activation of Wnt signalling leads to two distinct pathways to induce initial tumorigenesis or metastatic progression depending on the different transcriptional output of Wnt signal in a cell context dependent manner.
Could you discuss this? —Susanna, Liberia; Cheryl, Westchester City. A. Although we think of Alzheimer's as a single homogenous disease, it's more accurate to think of it as a constellation of closely related diseases with each genetic defect resulting in a unique pattern of progression depending on brain areas affected.
In conclusion, MMP9 has different effects on breast cancer progression depending on whether IGFBPs are expressed.
Among the 15 mRNAs found to be overexpressed, we focused on Immediate early gene X-1 (IEX-1) mRNA because of the recognized contribution of its expression to apoptosis or cell cycle progression, depending on the cell type and culture conditions.
It is remarkably heterogeneous both clinically and biologically, as there is a large variation in tumor progression depending on the age of the patient at the time of diagnosis and the tumor stage [1].
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Cell cycle progression depends on the activation of cyclin-dependent kinases (CDK), which act consecutively in G1 to initiate S phase and in G2 to initiate mitosis.
Thereafter, from dosages from one-quarter of WT to the WT-level, cell cycle progression depends on the ability to pass through G2.
Tumor growth and progression depends on their microenvironment, which undergoes constant co-evolution because of the dynamic tumor stormal interactions.
Cell cycle progression depends on a highly regulated series of events of which transcriptional control plays a major role.
The inflammatory response is a coordinated process that should be finely regulated if an efficient regenerative process is initiated; this progression depends on a balance between excessive and insufficient inflammatory activities (Tidball and Villalta, 2010).
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