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The hypothesis that components of bacteria may retard cancer progression dates back to William B. Coley's therapeutic experiments ("bacterial vaccine") in the 1890s.
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Study of magnetic delineations along the seamount have modeled the ridge's history up to 30 million years ago, and shown that growth has progressed mostly in the north, with some southward progression dating back 3.5 million years.
The progression date is the first visit date at which a patient is progressed or is referred to another health care provider for progression, as recorded in the medical record.
Progression-free survival (PFS) was calculated from the date of cetuximab initiation to the date of disease progression, date of death if it occurred before progression, or date of last news.
Data collected included standard demographics and disease characteristics, first date of treatment, best response to treatment and date of progression, date of death or last follow-up.
In patients who received study treatment without a progression date or death, PFSL will be censored on the date of last clinical assessment.
Duration of response was defined as the period from the first day the criteria for CR or PR were met to the progression date.
Progression-free survival was defined as the interval from the date of initial surgical resection to the date of progression, date of recurrence, or date of last known contact if the patient was alive and has not recurred.
Follow-up: Date of disease progression (if patient is withdrawn for reasons other than progression), Date of initiation and type of any second and subsequent lines of therapy, Date of death.
Date of disease progression (if patient is withdrawn for reasons other than progression), Date of initiation and type of any second and subsequent lines of therapy, Date of death.
The following data necessary for this study were collected: patients age at the time of diagnosis, height and weight, tumor histology and grade, date of cytoreductive surgery, date of disease progression, date of last visit, date of death.
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