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But for only those patients with the normal version of the gene, called KRAS, the drug reduced the risk of tumor progression by a much larger 32percentt.
Hoshijima, M. et al. Chronic suppression of heart-failure progression by a pseudophosphorylated mutant of phospholamban via in vivo cardiac rAAV gene delivery.
High-priced cancer medicines that delay progression by a few months, but do not represent a cure, have also come in for considerable criticism.
In this regard, the known tumor promoters stimulated cancer progression by a CAR-dependent perturbation of the expression of the growth arrest and DNA damage-inducible 45 beta (GADD45B) (Columbano et al., 2005), the murine double minute 2 (mdm2) (Huang et al., 2005), as well as the newly identified tubulin alpha 8 (TUBA8) (Kamino et al., 2011a).
The pro-inflammatory cytokines TNF-α, IL-1 and IL-6, by contrast, may promote cancer progression by a variety of other mechanisms, that are only now beginning to be elucidated [23], [33].
Third, the potential to metastasize might only be triggered late in progression, by a change in the tumor microenvironment [7], allowing the clone to expand, without the fitness penalty of emigration, before the change in the microenvironment.
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These data suggest that CDK11p58 might inhibit tumor proliferation and progression by an influence on angiogenesis.
A cross-sectional analysis in an adult population should reflect a differential atherogenic progression by an association between measured CIMT and long-term exposure to ambient air pollution.
The objective of this study was to identify potential candidate genes involved in AD development and progression by an integrative genomic convergence approach involving rank based scoring method.
Use of the DWT permitted the quantification of such responses, thus extending the length of the follow-up period of disease progression by an additional 16 years.
The Bayesian network models cancer progression by an explicit unobservable accumulation process in time that is separated from the observable but error-prone detection of mutations.
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