Therefore, they represent specific biomarkers not only to monitor disease progression but also to rationally design targeted nanomedicines.
Blood Gluc activity not only tracks metastatic tumor progression but also serves as a longitudinal biomarker for tumor response to treatments.
Thus, assessing these parameters could represent an interesting tool to monitor disease development and progression, but also the effects of drug treatments.
This information appears to be relevant not only for a better understanding of the disease progression but also for possible enrolment of patients in future trials.
We propose that p53 not only limits malignant progression by suppressing the acquisition of alterations that lead to tumour progression, but also, in the context of p53 restoration, responds to increased oncogenic signalling to mediate tumour regression.
Furthermore, an increased frequency of CD47+/MET+ CTCs among all CTCs detected in patients with luminal breast cancer was not only associated with more metastatic sites and disease progression, but also negatively correlated with prognosis109.
The active ingredient fluxapyroxad, belonging to the carboxamides chemical group, not only control fungal pathogens and reduce disease progression but also, might increase green leaf area duration of the crop.
However, drugs that have been designed to block angiogenesis mainly capture growth factors in circulation, resulting not only in the transient inhibition of tumor progression but also in producing undesirable side effects.
The complex network of biochemical and biophysical cues in the pancreatic desmoplasia not only presents challenges to the fundamental understanding of tumor progression, but also hinders the development of therapeutic strategies against pancreatic cancer.
In this way, neuroimaging in mouse models of neurological disorders not only can be used for phenotyping specific diseases and monitoring disease progression but also plays an essential role in the development and evaluation of disease-specific treatment approaches.
Many attempts have been made to develop a theory that would not only justify the principle of progression but also result in a mathematically exact scale of equitable taxation.
