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This means that it derives the crack location solely from C at any given moment, negating the need to visually monitor the crack progression as required by other methods [15].
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However, taking into account the limited number of studies investigating serum levels of leptin, adiponectin, and other adipokines in AS and their inconsistent results, as well as the fact that no study has assessed synovial fluid adipokine concentration in this disorder, the role of adipose tissue hormones in the development and progression of AS requires better understanding.
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