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In conclusion, in this study we have recognised a strictly defined sequential progression arising from the initial expression of E7 that rapidly transforms the cells.
This experimental model enabled us to recognise and follow a strictly defined sequential progression arising from the initial expression of E7 that rapidly transforms the cells.
I presented an assessment of physiological components that drive morphological transformation and solid tumor progression arising from the self-propagating tumor microenvironment.
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We now hypothesise that a similar model of progression arises in PCa: namely that subclones of cells harbouring AR gain/amplification and consequent overexpression arise in primary hormone naive tumours.
Those that reverse from a stripe pattern to a nodular pattern especially should be strictly followed up, because the majority of cases of local progression arose from the stripe pattern later than the 6-month follow-up after showing a shape transformation that did not conform to the typical tendency.
For instance, variations in disease progression may arise not only from host-genetic factors [4], [5], [61] but also from stochastic effects.
This model posits a parallel, independent progression of metastases arising from early DTCs (Klein, 2009).
Recent study proved that IL-10 is required for efficient immune surveillance against the incidence and progression of endogenously arising skin tumors.
The findings depicted in Figure 4 allow for insight into the heterogeneity in cognitive progressions that arise among MCI, and thus help in identifying profiles of high risk.
Insufficient accuracy of spleen TE could be partially explained by influence of various shunts, arising during progression of portal hypertension.
Recently, however, the concept of cancer as a multistep progression, with metastatic potential arising late within a rare cell, has been challenged [ 3- 5].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com