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There was also a significant interaction of first-line treatment regimen with Progression, in which patients in the taxane group showed almost no increase in fatigue scores at progression (about 0.1 points), whereas other patients saw scores increase 0.7 - 0.8 points at progression.
"There was no sense of progression about what the company was going to do from that point on.
The two CFH variants each independently increased risk of progression about two- to threefold, with similar increased risk for C3, comparing the homozygous risk and nonrisk genotypes.
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Can you tell us a little bit about how that progression came about?
From the survival curve, 1-year free of local-regional progression was about 87%, 1-year free of distant metastase was about 60%, and 1-year overall survival was about 70%, which were in good accordance with our study.
For us, everything the students do is a about progression; nobody is allowed to drift away.
The understanding about the dissociation between early and later disability progression and about the role of prognostic factors is central to the debate on the putative mechanisms of disability progression in multiple sclerosis.
InterMune said that when the results of its own two trials were pooled, pirfenidone reduced the risk of disease progression by about 25percentt.
Median time to progression was about 1.9 months, with median OS of 9.97 to 11.53 months.
Of the disorders commonly associated with acute lung injury (ALI), sepsis carries the highest risk of progression at about 40% [ 3, 4].
A clinical benefit rate of 50% and a median time-to progression of about 7 months are noteworthy, considering that a high proportion of these patients had visceral involvement and about a quarter had central nervous system metastases.
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